Solvothermal Synthesis, Characterization and Cytotoxicity Study of Cobalt and Copper of Complexes Sulfamethoxazole

Main Article Content

Usman Abubakar Adamu
Buhari Magaji
Adamu Baba Mohammad
Mukhtar Muhammad Sani
Zulaihat Isa Hussaini

Abstract

The complexes of Co and Cu with sulfamethoxazole (SMZ) were synthesized in the 1:2 molar ratios. The physical characterization of the ligand and the complexes showed different colours with a good % yield and high melting point/decomposition temperature. The solubility test of the metal complexes and the free drug using various solvents of different polarity and proticity showed that the free drug and the metal complexes are soluble in polar and non-polar solvents. The IR results of the synthesized complexes displayed new peaks that are not present in the free drug, the bands are due to M-O and M-N thus, confirming the coordination. The result from the conductivity measurement shows that the complexes are non-electrolyte. More so, all the complexes were found to be toxic in brine shrimp lethality assay.

Keywords:
Bioassay, brine shrimp, polar and non-polar solvents, sulfamethoxazole

Article Details

How to Cite
Adamu, U. A., Magaji, B., Mohammad, A. B., Sani, M. M., & Hussaini, Z. I. (2020). Solvothermal Synthesis, Characterization and Cytotoxicity Study of Cobalt and Copper of Complexes Sulfamethoxazole. Asian Journal of Physical and Chemical Sciences, 8(2), 6-12. https://doi.org/10.9734/ajopacs/2020/v8i230111
Section
Original Research Article

References

Rafique S, Idrees M, Nasim A, Akbar H, Athar A. Transition metal complexes as potential therapeutic agents. Biotech. Mol. Biol. Rev. 2010;5:38–45.

Dawara L, Joshi SC, Singh RV. Synthesis, characterization and antimicrobial and antispermatogenic activity of bismuth(III) and arsenic(III) derivatives of biologically potent nitrogen and sulfur donor ligands. Int. J. Inorg. Chem. 2012;4:1-8.
[ID: 372141]

Basu BTS. Antimicrobial activity of organotin(IV) compounds,” A. Organom. Chem. 2008;22:195–204.

Singh KDP, Singh M, Singh B, Tyagi P, Mirza Y. Some bivalent metal complexes of Schiff bases containing N and S donor atoms. J. Enzyme Inhib. Med. Chem. 2006;21(6):749-755.

Bruijnincx PC, Sadler PJ. New trends for metal complexes with anticancer activity. Curr. Opin. Chem. Biol. 2008;12(2):197-206.

Al-Shihri AS, Kalam A, Al-Sehemi AG, Du G, Ahmad T. One pot synthesis of Cobalt Ferrites nanoparticles via hydrothermal method and their optical studies. J. Indian Chem. Soc. 2014;91:1861.

Kiran VS, Sumathi S. Comparison of catalytic activity of bismuth substituted cobalt ferrite nanoparticles synthesized by combustion and co-precipitation method. J. Magn Magn. Mater. 2017;421: 113.

Mattei YC, Pérez OP, Uwakweh ONC. Effect of high-energy ball milling time on structural and magnetic properties of nanocrystalline cobalt ferrite powders. J. Magn. Magn. Mater. 2012;341:17.

Malik H, Mahmood A, Mahmood K, Lodhi MY, Warsi MF, Shakir I, Wahab H, Asghar M, Khan MA. Influence of cobalt substitution on the magnetic properties of zinc nanocrystals synthesized via micro-emulsion route. Ceram. Int. 2014;40:9439.

Meron T, Rosenberg Y, Lereah Y, Markovich G. Synthesis and assembly of high-quality cobalt ferrite nanocrystals prepared by a modified sol–gel technique. J. Magn. Magn. Mater. 2005;292:11.

Li S, Wang X. Synthesis of different morphologies lanthanum ferrite (LaFeO3) fibers via electrospinning. Optik. 2015;126: 408.

Marcela R. Chapter 5 Metal Complexes as Antimicrobial Agents, A Search for Antibacterial Agents Edited by Varaprasad Bobbarala Published by In Tech Janeza Trdine 9, 51000 Rijeka, Croatia; 2012.

Al-khodir FAI. Ca(II) Zn(II) and Au(III) sulfametazaxole sulfa-drugs complexes: synthesis, spectroscopic and anticancer evaluation studies. Orient. J. Chem. 2015;31(3):1277-1285.

Owolarafe TT, Owo T, Chimaobi JO. Phyto chemical investigation and brine shrimp lethality assay of extract of picralima (apoceanacea) staph. Seeds. A. J. Pharmacol. Toxic. 2014;2(3):11-15.

Cotton FA, Wilkinson G, Murillo CA, Bochman M. Advanced Inorganic Chemistry (6th ed.). New York; Fohnwiley and Sons; 1999.

Ghosh A, Banik S, Islam M. In vitro thrombolytic, anthelmintic, anti-oxidant and cytotoxic activity with phytochemical screening of methanolic extract of Xanthium indicum leaves. Bangladesh J. Pharmacol. 2015;10:854-59.

Maurer-Jones MA, Love SA, Meierhofer S, Marquis BJ, Liu Z, Haynes CL. Toxicity of nanoparticles to brine shrimp: An introduction to nanotoxicity and interdisciplinary science. J. Chem. Educ. 2013;90:475-78.

Nakamoto K. Infrared and raman spectra of inorganic and compound. New York: Wiley; 1978.

Meyer BN, Ferrigni NR, Putnam JE, Jacobsen LB, Nichols DE, McLaughlin JL. Brine shrimp: A convenient general bioassay for active plant constituents. Planta Medica. 1982;45:31-34.

Liou JP, Hsu KS, Kuo CC, Chang CY, Chang JY. A novel oral indoline-sulfonamide agent, N-1-(4-methoxybenzenesulfonyl)-2,3-dihydro-1H-indol-7-yl] isonicotinamide (J30), exhibits potent activity against human cancer cells in vitro and in vivo through the disruption of microtubule. J. Pharmacol. Exp. Therapeut. 2007;323(1):398- 405.