Synthesis, Spectral Characterization, In vitro α-Amylase, Antioxidative and Molecular Docking Studies of S-(5-methoxy-1H-benzimidazole-2-yl) Thiophene-2-carbothioate and Their Metal Complexes

Main Article Content

Manjuraj Thippeswamy
Krishnamurthy Ganganaik
Halehatti S. Bhojyanaik
Yadav D. Bodke

Abstract

The ligand S-(5-methoxy-1H-benzimidazole-2-yl) thiophene-2-carbothioate (BTC) and its Co(II), Ni(II), Cu(II) and Zn(II) metal complexes have been synthesized, structurally characterized by physicochemical and spectroscopic tools (Uv-vis, FT-IR, NMR, Lc-mass). The powder XRD analysis was carried out for Co(II), Ni(II) and Cu(II) complexes, indicates the crystalline nature of the complexes. The In vitro α-Amylase activity was performed by using porcine pancreatic amylase in Tris–HCl buffer; in-vitro antifungal activity was carried out by fungal strains Candida albicans, Aspergillus flavus and Microspore arises using agar well diffusion method. The DPPH radical scavenging activity was also performed for the ligand and their metal complexes and allied with docking interactions with a human antioxidant enzyme in complex with the competitive inhibitor DTT (PDB ID: 3NMG).

 

Keywords:
2-mercapto benzimidazole, metal complexes, XRD, α-Amylase, DPPH, docking

Article Details

How to Cite
Thippeswamy, M., Ganganaik, K., S. Bhojyanaik, H., & D. Bodke, Y. (2018). Synthesis, Spectral Characterization, In vitro α-Amylase, Antioxidative and Molecular Docking Studies of S-(5-methoxy-1H-benzimidazole-2-yl) Thiophene-2-carbothioate and Their Metal Complexes. Asian Journal of Physical and Chemical Sciences, 5(1), 1-14. https://doi.org/10.9734/AJOPACS/2018/39565
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Original Research Article